Epigenetic Regulation of normal hematopoiesis and its dysregulation in myeloid neoplasia

Functional examination of H3K4 methyltransferases in myeloid neoplasia






  • Denissov S, Hofemeister H, Marks H, Kranz A, Ciotta G, Singh S, Anastassiadis K, Stunnenberg HG, Stewart AF. Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant. Development. 2014 Feb;141(3):526-37. PMID:24423662


  • Singh, R. P., Franke, K., Kalucka, J., Mamlouk, S., Muschter, A., Gembarska, A., Grinenko, T., Willam, C., Naumann, R., Anastassiadis, K., Stewart, A. F., Bornstein, S., Chavakis, T., Breier, G., Waskow, C. and Wielockx, B. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 2013 Jun 27;121(26):5158-66. PMID:23667053

    • Francis Stewart


    Biotechnology Center TU Dresden
    (Biotech)
    Tatzberg 47/49
    01307 Dresden
    Phone: +49 351 46340129
    Fax: +49 351 46340143


    Andrea Kranz


    Biotechnology Center TU Dresden
    (Biotech)
    Tatzberg 47/49
    01307 Dresden
    Phone: +49 351 46340152
    Fax: +49 351 46340143


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