Epigenetic Regulation of normal hematopoiesis and its dysregulation in myeloid neoplasia

  • Development of integrative methods for the analysis of epigenetic data on myeloid neoplasia
       Leiter: Brors, Benedikt

  • Dissecting the role of PIWIL4 as a novel epigenetic factor in acute myeloid leukemia
       Leiter: Buske, Christian; Rawat, Vijay Pal Singh

  • Disordered epigenetic regulation of the CREBBP oncoprotein and of micro-RNA transcription in juvenile myelomonocytic leukemia at high risk of relapse
       Leiter: Flotho, Christian

  • Functional analysis of somatic cancer mutations in human DNA methyltransferases
       Leiter: Jeltsch, Albert

  • Reversible histone acetylation and its inhibitors in myeloid neoplasia
       Leiter: Jung, Manfred

  • Epigenetic function of RUNX1 with PRMT6 in normal and aberrant myeloid differentiation
       Leiter: Lausen, Jörn

  • Computational model of epigenetic regulation of myeloid differentiation during homoeostasis and malignant transformation
       Leiter: Löffler, Markus; Galle,Jörg, Jörn

  • Combined epigenetic therapy of acute myeloid leukemia: translational studies of in vivo induction of gene expression and DNA hypomethylation
       Leiter: Lübbert, Michael

  • Comparative characterization of azacytidine-induced RNA and DNA demethylation in myeloid leukemia
       Leiter: Lyko, Frank

  • Functional analysis of KDM6A histone demethylase in the regulation of HSC development and in leukemogenesis
       Leiter: Müller, Albrecht M.; Becker, Matthias

  • The significance of DNA methyltransferase inhibition and DNA methylation for therapy response in acute myeloid leukemia
       Leiter: Müller-Tidow, Carsten

  • Epigenetic dysregulation of transcription factor NF-E2 expression in the pathophysiology of myeloproliferative neoplasms
       Leiter: Pahl, Heike

  • Genetic and epigenetic search for tumor suppressor genes on chromosome 7q in acute myeloid leukemia
       Leiter: Plass, Christoph; Döhner, Hartmut; Lipka, Daniel

  • Functional evaluation of DNA methylation-controlled leukemia stem cell genes
       Leiter: Rosenbauer, Frank; Andrade-Navarro, Miguel; Savelyeva, Irina

  • Epigenetic consequences of MLL fusion protein expression
       Leiter: Slany, Robert

  • Functional examination of H3K4 methyltransferases in myeloid neoplasia
       Leiter: Stewart, Francis; Kranz, Andrea